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See detailCognitive Decline and Labor Market Activity
Dupuy, Arnaud UL; De Grip, Andries; Jolles, Jelle et al

in Economics and Human Biology (2015)

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See detailA meta-analysis on the effectiveness of bilingual programs in Europe
Aleksic, Gabrijela UL; Ferring, Dieter UL; Martin, Romain UL

in Review of Educational Research (2015), 85(1), 92-128

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates ... [more ▼]

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates this topic for the first time in the European context. Thorough literature searches uncovered 101 European studies, with only seven meeting the inclusion criteria. Two studies were excluded from further analyses. Results from the random-effects model of the five remaining studies indicate a small positive effect (g = 0.23; 95% CI [0.10, 0.36]) for bilingual over submersion programs on reading of language-minority children. Thus, this meta-analysis supports bilingual education—that is, including the home language of language-minority children—in school instruction. However, the generalizability of the results is limited by the small number of studies on this topic. More published studies on bilingual education in Europe are needed as well as closer attention to the size of the effects. [less ▲]

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See detailHierarchical Organization and Performance Inequality: Evidence from Professional Cycling
Dupuy, Arnaud UL; Candelon, Bertrand

in International Economic Review (2015)

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See detailCanonical correlation and assortative matching: a remark
Dupuy, Arnaud UL; Galichon, Alfred

in Annales d'Economie et de Statistique = Annals of Economics and Statistics (2015)

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See detailThe Assignment of Workers to Tasks with Endogenous Supply of Skills
Dupuy, Arnaud UL

in Economica (2015)

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See detailA shift in paradigm towards human biology-based systems for cholestatic-liver diseases.
Noor, Fozia UL

in The Journal of physiology (2015), 593(23), 5043-55

Cholestatic-liver diseases (CLDs) arise from diverse causes ranging from genetic factors to drug-induced cholestasis. The so-called diseases of civilization (obesity, diabetes, metabolic disorders, non ... [more ▼]

Cholestatic-liver diseases (CLDs) arise from diverse causes ranging from genetic factors to drug-induced cholestasis. The so-called diseases of civilization (obesity, diabetes, metabolic disorders, non-alcoholic liver disease, cardiovascular diseases, etc.) are intricately implicated in liver and gall bladder diseases. Although CLDs have been extensively studied, there seem to be important gaps in the understanding of human disease. Despite the fact that many animal models exist and substantial clinical data are available, translation of this knowledge towards therapy has been disappointingly limited. Recent advances in liver cell culture such as in vivo-like 3D cultivation of human primary hepatic cells, human induced pluripotent stem cell-derived hepatocytes; and cutting-edge analytical techniques such as 'omics' technologies and high-content screenings could play a decisive role in deeper mechanistic understanding of CLDs. This Topical Review proposes a roadmap to human biology-based research using omics technologies providing quantitative information on mechanisms in an adverse outcome/disease pathway framework. With modern sensitive tools, a shift in paradigm in human disease research seems timely and even inevitable to overcome species barriers in translation. [less ▲]

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See detailD'Atlantropa à Desertec: macro-projeter le continent ressource du 20e siècle
Hertweck, Florian UL; Lopez, Fanny

in Rouillard, Dominique (Ed.) Afriques. Architecture, infrastructures et territoires en devenir (2015)

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See detailA meta-analysis of the effectiveness of bilingual programs in Europe
Aleksic, Gabrijela UL; Ferring, Dieter UL; Martin, Romain UL

in International Congress on Education, Innovation and Learning Technologies (2014, July)

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates ... [more ▼]

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates this topic for the first time in the European context. Thorough literature searches uncovered 101 European studies, with only seven meeting the inclusion criteria. Two studies were excluded from further analyses. Results from the random-effects model of the five remaining studies indicate a small positive effect (g = 0.23; 95% CI [0.10, 0.36]) for bilingual over submersion programs on reading of language-minority children. Thus, this meta-analysis supports bilingual education—that is, including the home language of language-minority children—in school instruction. However, the generalizability of the results is limited by the small number of studies on this topic. More published studies on bilingual education in Europe are needed as well as closer attention to the size of the effects. [less ▲]

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See detailA meta-analysis of the effectiveness of bilingual programs in Europe
Aleksic, Gabrijela UL; Ferring, Dieter UL; Martin, Romain UL

Scientific Conference (2014, June)

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates ... [more ▼]

The effectiveness of bilingual programs for promoting academic achievement of language-minority in the United States has been examined in six meta-analyses. The present meta-analytic study investigates this topic for the first time in the European context. Thorough literature searches uncovered 101 European studies, with only seven meeting the inclusion criteria. Two studies were excluded from further analyses. Results from the random-effects model of the five remaining studies indicate a small positive effect (g = 0.23; 95% CI [0.10, 0.36]) for bilingual over submersion programs on reading of language-minority children. Thus, this meta-analysis supports bilingual education—that is, including the home language of language-minority children—in school instruction. However, the generalizability of the results is limited by the small number of studies on this topic. More published studies on bilingual education in Europe are needed as well as closer attention to the size of the effects. [less ▲]

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See detailFinal report of the effectiveness study in Virtual Coach Reaches Out to me project
Aleksic, Gabrijela UL; Roelofsma, Peter

Report (2014)

One out of three persons in our society suffers from social or emotional loneliness. This percentage is even higher in the population of people who suffer from chronic diseases. Loneliness has pervasive ... [more ▼]

One out of three persons in our society suffers from social or emotional loneliness. This percentage is even higher in the population of people who suffer from chronic diseases. Loneliness has pervasive effects on mental health but it also has negative effects on physical well-being. The aim of this paper is to present a series of pilot studies evaluating the development of an ambient virtual coaching system. This system, called V2me (Virtual Coach reaches Out to Me) offers a friendship enrichment course for people in need for improving their social network. Several pilot studies were performed with about 50 participants in total who evaluated the system that was developed using a living lab approach. In this approach new health media was developed from a user-centered process that allows frequent iterations of user evaluation and involvement. The paper presents the results of the first five iterations. The reactions on receiving the system and experiences during instruction were increasingly positive over these iterations of the system development phase. Over time the system has passed the user’s choice selection criteria. Participants have been expressing a clear interest for choosing and wanting to use the system in their daily lives. However, the system did not pass the persistent use selection criteria when the system was brought and left for independent use. It appeared that participants did not use it very much during the day as expected. Moreover, participants did not perform all the tasks (i.e., messaging, Skyping) that they were asked to achieve on a daily basis. The final goal of the V2me system, i.e. establishing social relations between elderly persons, was not achieved as well, although this might be due to the limited time space of using the system and its facilities. Given these observation, it is concluded that more iterations in the system development are needed for the system in order to pass the habitual use criteria which is needed for its effectiveness. [less ▲]

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See detailPersonality traits and the marriage market
Dupuy, Arnaud UL; Galichon, Alfred

in Journal of Political Economy (2014)

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See detailEntropy Methods for Identifying Hedonic Models
Dupuy, Arnaud UL; Galichon, Alfred; Henry, Marc

in Mathematics and Financial Economics (2014)

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See detailOn Input Market Frictions and Estimation of Factors Demand
Dupuy, Arnaud UL; Sorensen, Todd

in Southern Economic Journal (2014)

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See detailState-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
Alepee, Natalie; Bahinski, Anthony; Daneshian, Mardas et al

in ALTEX (2014), 31(4), 441-77

Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk ... [more ▼]

Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment; and (iii) increase our understanding of disease. Three-dimensional (3D) cell culture models are important building blocks of this strategy which has emerged during the last years. The majority of these models are organotypic, i.e., they aim to reproduce major functions of an organ or organ system. This implies in many cases that more than one cell type forms the 3D structure, and often matrix elements play an important role. This review summarizes the state of the art concerning commonalities of the different models. For instance, the theory of mass transport/metabolite exchange in 3D systems and the special analytical requirements for test endpoints in organotypic cultures are discussed in detail. In the next part, 3D model systems for selected organs--liver, lung, skin, brain--are presented and characterized in dedicated chapters. Also, 3D approaches to the modeling of tumors are presented and discussed. All chapters give a historical background, illustrate the large variety of approaches, and highlight up- and downsides as well as specific requirements. Moreover, they refer to the application in disease modeling, drug discovery and safety assessment. Finally, consensus recommendations indicate a roadmap for the successful implementation of 3D models in routine screening. It is expected that the use of such models will accelerate progress by reducing error rates and wrong predictions from compound testing. [less ▲]

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See detailLong-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study.
Klein, Sebastian; Mueller, Daniel; Schevchenko, Valery et al

in Journal of applied toxicology : JAT (2014), 34(10), 1078-86

Chronic repeated-dose toxicity studies are still carried out on animals and often do not correlate with the effects in human beings mainly due to species-specific differences in biotransformation. The ... [more ▼]

Chronic repeated-dose toxicity studies are still carried out on animals and often do not correlate with the effects in human beings mainly due to species-specific differences in biotransformation. The human hepatoma cell line HepaRG has been used for human relevant toxicity assessment. However, HepaRG cells are commonly maintained in serum containing medium which limits their use in 'omics'-based toxicology. In this study, we compared the maintenance of HepaRG cells in standard serum-supplemented and serum-free conditions. Viability and Cytochrome P450 (CYP) activity during long-term cultivation were assessed. Liver-specific albumin and urea production was measured. The extracellular metabolome (amino acids, glucose, lactate and pyruvate) was measured to compare different cultivation conditions using metabolic flux analysis. Although metabolic flux analysis reveals differences in certain parts of the metabolism, e.g. production of urea, the overall metabolism of serum-free and serum-supplemented cultured HepaRG cells is similar. We conclude that HepaRG cells can be maintained in optimized serum-free conditions for 30 days without viability change and with high CYP activity. We also tested the acute (24 h) and long-term repeated-dose (7 doses, every second day) toxicity of valproic acid. We calculated an EC50 value of 1.4 mM after repeated exposure which is close to the cmax value for valproic acid. Maintenance of HepaRG cells in serum-free conditions opens up the opportunity for the use of these cells in human long-term repeated-dose hepatotoxicity studies and for application in systems toxicology. [less ▲]

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See detail3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies.
Mueller, Daniel; Kramer, Lisa; Hoffmann, Esther et al

in Toxicology in vitro : an international journal published in association with BIBRA (2014), 28(1), 104-12

Predictive in vitro models alternative to in vivo animal will have a significant impact in toxicology. Conventional 2D models do not reflect the complexity of a 3D organ resulting in discrepancies between ... [more ▼]

Predictive in vitro models alternative to in vivo animal will have a significant impact in toxicology. Conventional 2D models do not reflect the complexity of a 3D organ resulting in discrepancies between experimental in vitro and in vivo data. Using 3D HepaRG organotypic cultures we tested four drugs (aflatoxin B1, amiodarone, valproic acid and chlorpromazine) for toxic effects and compared the results with 2D HepaRG and HepG2 cultures. We show that 3D HepaRG cultures are more sensitive than the other tested cultures to aflatoxin B1 which is only toxic upon metabolic activation in the liver. We observed that CYP3A4 activity is higher in the 3D HepaRG cultures compared to the 2D HepaRG cultures. Furthermore, we investigated repeated dose toxicity of chlorpromazine and assessed its effects on glucose and lactate metabolism. Sub-toxic concentrations of chlorpromazine induced significant metabolic changes in both 2D and 3D HepaRG cultures upon acute and repeated dose (3 doses) exposure. In summary, our data support the hypothesis that 3D cell culture models better mimic the in vivo tissue and improve cellular functionality. The 3D HepaRG organotypic cultures represent a high throughput system for drug toxicity screening. This system is therefore a promising tool in preclinical testing of human relevance which can allow reducing and/or replacing animal testing for drug adverse effects. [less ▲]

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See detailDie Bevölkerung der Großregion SaarLorLux
Interregionale Arbeitsmarktbeobachtungsstelle, IBA; Pauly, Michel UL; Caruso, Geoffrey UL et al

E-print/Working paper (2014)

Der Beitrag ist ein Auszug aus dem Bericht zur wirtschaftlichen und sozialen Lage der Großregion 2013/2014 für den Wirtschafts- und Sozialausschuss der Großregion (WSAGR) (IBA/OIE, 2014, S.3-10). Die ... [more ▼]

Der Beitrag ist ein Auszug aus dem Bericht zur wirtschaftlichen und sozialen Lage der Großregion 2013/2014 für den Wirtschafts- und Sozialausschuss der Großregion (WSAGR) (IBA/OIE, 2014, S.3-10). Die Karten zeigen die Bevölkerungsdichte in der Großregion zum 1. Januar 2013, die Bevölkerung im erwerbsfähigen Alter zum 1. Januar 2012 sowie die Bevölkerungsentwicklung von 2000 bis 2013 (Lothringen: zones d'emploi 1999-2011), berechnet durch die Interregionale Arbeitsmarktbeobachtungsstelle IBA. Die Bevölkerungsdichte der Großregion lag 2013 bei beinahe 175 Einwohnern je km2. Allerdings zeigt sich regional eine sehr unterschiedliche Verteilung: von mehr als 2 000 Einwohnern je km2 in Mainz und Ludwigshafen bis hin zu den dünn besiedelten Gebieten Verdun und Commercy mit weniger als 30 Einwohnern je km2. Der größte Verdichtungsraum bildet sich im Osten von Rheinland-Pfalz entlang der Rheinschiene. Hier liegen wichtige wirtschaftliche Schwerpunkte und es wirken Einflüsse der großen Ballungszentren benachbarter Bundesländer. Dicht besiedelte Gebiete befinden sich außerdem im nördlichen Teil der Wallonie – insbesondere in den Wirtschaftszentren Charleroi und Lüttich. Daneben konzentriert sich die Bevölkerung der Großregion vor allem auf ein länderübergreifendes Kerngebiet, das alle Teilräume sowie wichtige wirtschaftliche Schwerpunkte umfasst. [less ▲]

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