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See detailAbsence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease
Ashrafi, Amer UL; Garcia, Pierre UL; Kollmus, Heike et al

in Neurobiology of Aging (in press)

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy ... [more ▼]

Regulator of G-Protein Signaling 4 (RGS4), a member of the RGS family of proteins that inactivate G-proteins, has gained interest as a potential drug target for neurological disorders, such as epilepsy and Parkinson’s disease (PD). In the case of PD, the main current option for alleviating motor symptoms are dopamine replacement therapies, which have limitations because of side effects, and reduced effectiveness over the long term. Research on new non-dopaminergic PD drug targets has indicated that inhibition of RGS4 could be an effective adjuvant treatment option. The effectiveness of RGS4 inhibition for an array of PD-linked functional and structural neuroprotection endpoints has not yet been demonstrated. Here, we use the 6-Hydroxydopamine (6-OHDA) lesioning model of the nigrostriatal pathway in mice to address this question. We observe, using a battery of behavioral and pathological measures, that mice deficient for RGS4 are not protected from 6-OHDA induced injury, and show enhanced susceptibility in some measures of motor function. Our results suggest that inhibition of RGS4 as a non-dopaminergic target for PD should be approached with caution. [less ▲]

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See detail(Re)shaping Educational Research through ‘Programification’: Institutional Expansion, Change, and Translation in Norway
Zapp, Mike UL; Helgetun, Jo B.; Powell, Justin J W UL

in European Journal of Education (in press), 52

Educational research in Norway has experienced unprecedented structural expansion as well as cognitive shifts over the past two decades, especially due to increased state investments and the strategic use ... [more ▼]

Educational research in Norway has experienced unprecedented structural expansion as well as cognitive shifts over the past two decades, especially due to increased state investments and the strategic use of extensive and multi-year thematic programs to fund research projects. Applying a neo-institutionalist framework, we examine institutionalization dynamics in cultural-cognitive, normative, and regulative dimensions over the past two decades using interviews, research program calls, policy documents, and funding data. In the cultural-cognitive dimension, we find references to the knowledge society, the importance of evidence in policy-making, and ideas of quality, excellence, and relevance. In the normative dimension, we find the introduction of new professional and methodological standards, reflecting broader global patterns of academic and epistemic drift. In the regulative dimension, the strengthened role of both government and the Research Council of Norway is manifest in substantial growth in both funding and large-scale, long-term planning, including thematic choices—evidence of ‘programification’. The importance of external models has grown in an era of internationalization, yet translation occurs at every level of governance of educational research. This results in a specific Norwegian research model, guided by a mode of governance of programs, that maintains social values traditionally strong in Nordic societies. [less ▲]

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See detailThe Case for Context-Driven Software Engineering Research
Briand, Lionel UL; Bianculli, Domenico UL; Nejati, Shiva UL et al

in IEEE Software (in press)

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See detailCharacterizations of idempotent discrete uninorms
Couceiro, Miguel; Devillet, Jimmy UL; Marichal, Jean-Luc UL

in Fuzzy Sets & Systems (in press)

In this paper we provide an axiomatic characterization of the idempotent discrete uninorms by means of three conditions only: conservativeness, symmetry, and nondecreasing monotonicity. We also provide an ... [more ▼]

In this paper we provide an axiomatic characterization of the idempotent discrete uninorms by means of three conditions only: conservativeness, symmetry, and nondecreasing monotonicity. We also provide an alternative characterization involving the bisymmetry property. Finally, we provide a graphical characterization of these operations in terms of their contour plots, and we mention a few open questions for further research. [less ▲]

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See detailLe Brexit et les accords mixtes de l'Union européenne
Neframi, Eleftheria UL

in Annuaire Français de Droit International (in press)

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See detailIs medicine use for nervousness associated with adolescent at-risk or problem gambling ?
Canale, Natale; Vieno, Alessio; Billieux, Joël UL et al

in European Addiction Research (in press)

Objective: To examine the association between adolescent at-risk or problem gambling (ARPG) and medicine used to treat nervousness in a large-scale nationally representative sample of Italian adolescents ... [more ▼]

Objective: To examine the association between adolescent at-risk or problem gambling (ARPG) and medicine used to treat nervousness in a large-scale nationally representative sample of Italian adolescents. Study design: Data from the 2013 to 2014 Health Behaviour in School-aged Children Survey was used for cross-sectional analyses (a sample of 20,791 15-year-old students). Self-administered questionnaires were completed by a representative sample of high-school students. Respondents’ ARPG, use of medicine for nervousness and potential confounding factors were assessed. Multilevel logistic regression analyses were used to test the association between medicine use to treat nervousness and ARPG. Results: The overall prevalence of adolescents reporting medicine use for nervousness in the last month was 6.3%. The odds of ARPG were 3 times higher among adolescents who used medicine for nervousness compared to that among adolescents who did not take such medicine (OR 2.96, 95% CI 2.07–4.25). Importantly, the association between medicine used to treat nervousness and ARPG did not vary significantly when viewed in light of psychological symptoms. Conclusions: Medicine use to treat nervousness is associated with increased risk of gambling-related harm. [less ▲]

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See detailGrenze als überwindbares Phänomen in der Raumplanung?
Nienaber, Birte UL

in Heintel, Martin; Musil, Robert; Weixlbaumer, Norbert (Eds.) Grenzen (in press)

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See detailAere 'octroyed constitutions' of the 19th century to be considered as 'imposed constitutions'?
Gerkrath, Jörg UL

in Contiades, Xenophon (Ed.) ‘Imposed Constitutions: Aspects of Imposed Constitutionalism’ (in press)

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See detailLettere alla redazione : il caso della “Buona Domenica” lussemburghese Un fenomeno mediatico italo-lussemburghese
Cicotti, Claudio UL

in El Ghibli - Rivista di Letteratura della Migrazione (in press)

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See detailEnlarging the frame: Issues of inclusion and mental health in an ageing society
Ferring, Dieter UL; Murdock, Elke UL

in Journal of Mental Health Research in Intellectual Disabilities (in press)

This contribution frames the notions of inclusion and mental health by describing trends in European societies at the social and economic level that will have direct consequences for a participative civil ... [more ▼]

This contribution frames the notions of inclusion and mental health by describing trends in European societies at the social and economic level that will have direct consequences for a participative civil society and social cohesion. Starting point is the observation that the world faces challenges at the start of the 21st century that are new and unprecedented in its history. The four global forces that break all the trends known so far in human history include urbanization, accelerating technological development, greater global connections, and population ageing. The authors first describe the scale of population ageing, as ageing populations characterize several developed economies. In a second step, they highlight some consequences of population ageing for social welfare and in a third part they elaborate on the notion of justice and inclusion in rapidly changing societies. [less ▲]

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See detailLa force intégrative du statut de l'Etat membre sur la fonction juridictionnelle
Neframi, Eleftheria UL

in Potvin Solis, Laurence (Ed.) Le statut d'Etat membre de l'Union européenne (in press)

The integrative force of the Member States’ status on the judicial function is expressed through the loyalty obligation to provide remedies sufficient to ensure effective legal protection in the fields ... [more ▼]

The integrative force of the Member States’ status on the judicial function is expressed through the loyalty obligation to provide remedies sufficient to ensure effective legal protection in the fields covered by Union law (Art 19, par 1, subpar 2, TEU). Member States have to ensure access to the national judge, who has been entrusted with a European mandate, and who is in measure to cooperate with the Court of Justice through the preliminary reference procedure. The Member States establish in this way an integrated judicial function. The exercise of such a function by the national judge, in cooperation with the Court of Justice and under the control of the Member State, implies integrative dynamic, which however depends on the balancing exercise with national procedural autonomy and the margin of appreciation of the national judge. [less ▲]

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See detailStandards for duty of care? Debating intermediary liability from a sectoral perspective
Ullrich, Carsten UL

in Journal of Intellectual Property, Information Technology and Electronic Commerce Law (in press), 8(2),

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See detailEvaluation of school tasks in the light of sustainability education: Textbook research in science education in Luxembourgish primary schools
Andersen, Katja Natalie UL

in Environmental Education Research (in press)

This article describes a research project that aimed to classify different types of sustainability-related school tasks in terms of two central approaches in primary school education: action-based and ... [more ▼]

This article describes a research project that aimed to classify different types of sustainability-related school tasks in terms of two central approaches in primary school education: action-based and task-based learning. Using a textbook analysis approach, the article clarifies implicit and explicit forms of sustainability education in school tasks in Luxembourgish science textbooks for Grades 1 to 6. The study uses a two-step analysis: first, scanning textbooks on content relating to sustainability; and, second, evaluating the teaching practices associated with this content apparent in the textbooks. Step one identifies the school tasks in which sustainability content is implicitly or explicitly addressed while step two analyzes which forms of action-based and task-based learning occur in these sustainability-related school tasks. Based on the results two claims can be made: first, that there is very little sustainability-related content in Luxembourgish primary science textbooks, and those topics raised mostly relate to sustainability only indirectly; secondly, action-based and task-based learning are undervalued in the context of sustainability-related school tasks; neither of the two was commonly found in school tasks in sustainability education. [less ▲]

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See detailMulti-objective regression test selection in practice: an empirical study in the defense software industry
Özkan, Ramazan; Garousi, Vahid UL; Betin-Can, Aysu

in Proceedings of ACM/IEEE International Symposium on Empirical Software Engineering and Measurement (ESEM) (in press)

Executing an entire regression test suite after every code change is often costly in large software projects. To address this challenge, various regression test selection techniques have been proposed in ... [more ▼]

Executing an entire regression test suite after every code change is often costly in large software projects. To address this challenge, various regression test selection techniques have been proposed in the literature. One of those approaches is the Multi-Objective Regression Test Optimization (MORTO) approach, which is applied when there are multiple objectives during regression testing (e.g., minimizing the number of test cases and maximizing test coverage). This paper reports an action research type of study which was conducted to improve regression test-selection practices of a safety-critical industrial software in the defence domain based on the MORTO approach. The problem is formulated and solved by converting the multi-objective genetic-algorithm (GA) problem into a custom-built scalarized single-objective GA. The empirical results demonstrate that this approach yields a more efficient test suite (in terms of testing cost and benefits) compared to the old (manual) test-selection approach and another approach from the literature, i.e., the selective requirement coverage-based approach. Based on the context and need of the company, we developed the GA-based solution on a set of five cost objectives and four benefit objectives for regression testing while providing full coverage of the affected (changed) requirements. Since our proposed approach has been beneficial in the industrial context, it is currently in active use in the company. [less ▲]

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See detailHigher Education Systems and Institutions, Luxembourg
Harmsen, Robert UL; Powell, Justin J W UL

in Shin, J.C.; Teixeira, P. (Eds.) Encyclopedia of International Higher Education Systems and Institutions (in press)

Bordered by Belgium, France, and Germany, Luxembourg is one of the three main seats of the European Union’s institutions. The Grand Duchy of Luxembourg sits at the crossroads between Europe’s Germanic and ... [more ▼]

Bordered by Belgium, France, and Germany, Luxembourg is one of the three main seats of the European Union’s institutions. The Grand Duchy of Luxembourg sits at the crossroads between Europe’s Germanic and Francophone language communities. The country has experienced remarkable migratory flows, resulting in an ethnically hyper-diverse and multilingual population. Reflecting this cultural diversity, the educational system at all levels emphasizes language learning. Historically an agrarian society, a century ago it developed a very strong steelmaking industry and over the past decades has witnessed extraordinary growth in its financial services sector. Established to broaden the economic bases of the country, thus reducing overreliance on the steel and banking industries, yet against considerable pecuniary and ideological resistance, the national flagship University of Luxembourg (UL) was founded in 2003 upon initiative of a small group of elite decisionmakers. As a private, government-dependent institution (établissement public) directed by a Board of Governors (Conseil de Gouvernance), the university’s major funding is provided by the state, although its third-party funding has increased rapidly and substantially. Ironically, while spatial mobility is everywhere supported, Luxembourg has invested considerable capital and strategic planning in establishing its own national university. It aims to compete globally by concentrating its intellectual and financial resources and by building on the country’s strengths and priorities. The state took this ambitious step in scientific capacity-building in founding a research-oriented university, in so doing also providing a stay-at-home alternative for Luxembourg’s youth, traditionally educated abroad. The long-standing custom of educating elites in other countries was ostensibly justified by the establishment of cosmopolitan, Europe-wide networks. Today, rising international competition and supranational coordination have increased pressure on Luxembourg to grow its higher education system and thus also foster educational and scientific innovation. The University provides a means to diversify the economy and to integrate citizens from diverse cultural background, while the polity remains dominated by local elites. Oriented towards the Grand Duchy’s unique context—small size, but simultaneously flourishing center of European governance and international business—the University was founded upon the principles of internationality, multilingualism, and interdisciplinarity. [less ▲]

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See detailHow does research evaluation impact educational research? Exploring intended and unintended consequences of research assessment in the United Kingdom, 1986–2014
Marques, Marcelo UL; Powell, Justin J W UL; Zapp, Mike UL et al

in European Educational Research Journal (in press)

Research evaluation systems in many countries aim to improve the quality of higher education. Among the first such systems, the UK's Research Assessment Exercise (RAE) from 1986 is now the Research ... [more ▼]

Research evaluation systems in many countries aim to improve the quality of higher education. Among the first such systems, the UK's Research Assessment Exercise (RAE) from 1986 is now the Research Excellence Framework (REF). Highly-institutionalized, it holds research(ers) accountable. While studies describe the effects at different levels, this longitudinal analysis examines the gradual institutionalization and (un)intended consequences from 1986 to 2014. First, we analyze historically RAE/REF's rational, formalization, standardization, and transparency, framing it as a strong research evaluation system. Second, we locate the multidisciplinary field of education, analyzing submission behavior (staff, outputs, funding) of Departments of Education over time. We find: decreases in submitted staff; the research article as preferred publication format; the rise of quantitative analysis; and high and stable concentration of funding among few Departments. Policy instruments invoke varied responses, wit such reactivity shown by the increasing selectivity of submitted staff as a form of reverse engineering and the research article as the preferred output as a self-fulfilling prophecy. The funding concentration manifests an intended consequence, facilitating greater disparities between Departments of Education. These findings emphasize how research assessment impacts the structural organization and cognitive development of educational research in the UK. [less ▲]

Detailed reference viewed: 29 (3 UL)