[en] Hair presents several advantages for biomonitoring the exposure to pollutants. For
instance, this matrix is representative of the mid to long term exposure depending on the
length of the sample. However the question concerning the hair incorporation mechanism
of chemicals remain partially unravelled.
The subject of the present PhD was the “study of the incorporation mechanisms of
organic chemicals into hair” (StICHa). Therefore we focused on the influence of biological
and physicochemical parameters on the incorporation of pesticides into hair.
The results presented in the project were obtained from three experiments whose
two animal experiments conducted on rats. The first one allowed to link levels of exposure
of pesticides to the corresponding concentrations in plasma and in hair. This also allowed
to study the accumulation of pesticides in the rat body over time and to investigate the
influence of the pesticide physicochemical properties on their incorporation into hair. The
second one provided pharmacokinetic (PK) parameters of pesticides in blood after a single
exposure and highlighted the concept of background exposure corresponding to the
detectable chemicals concentration in the animals before exposure due to environmental
contamination. An in vitro test was also conducted to investigate bonds between pesticides
and blood components and their influence on hair incorporation.
