Cerebellar Diseases/metabolism/pathology; Humans; Lewy Body Disease/metabolism/pathology; Parkinson Disease/metabolism/pathology; alpha-Synuclein/metabolism
Abstract :
[en] Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha-synuclein in precerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait, and impaired balance, which may be associated with cerebellar dysfunction. Therefore, we screened the cerebella of 12 patients with alpha-synucleinopathies for neuropathological changes. Cerebellar nuclei and neighboring white matter displayed numerous aggregates, whereas lobules were mildly affected. Cerebellar aggregation pathology may suggest a prionlike spread originating from affected precerebellar structures, and the high homogeneity between patients with dementia with Lewy bodies and Parkinson disease shows that both diseases likely belong to the same neuropathological spectrum. Ann Neurol 2017;81:898-903.
Disciplines :
Neurology
Author, co-author :
Seidel, Kay
Bouzrou, Mohamed
Heidemann, Nina
Krüger, Rejko ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Schols, Ludger
den Dunnen, Wilfred F. A.
Korf, Horst-Werner
Rub, Udo
External co-authors :
yes
Language :
English
Title :
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.
Publication date :
June 2017
Journal title :
Annals of Neurology
ISSN :
1531-8249
Publisher :
John Wiley & Sons, Hoboken, United States - New York