Reference : Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/10993/32463
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.
English
Seidel, Kay [> >]
Bouzrou, Mohamed [> >]
Heidemann, Nina [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Schols, Ludger [> >]
den Dunnen, Wilfred F. A. [> >]
Korf, Horst-Werner [> >]
Rub, Udo [> >]
Jun-2017
Annals of neurology
81
6
898-903
Yes (verified by ORBilu)
0364-5134
1531-8249
United States
[en] Cerebellar Diseases/metabolism/pathology ; Humans ; Lewy Body Disease/metabolism/pathology ; Parkinson Disease/metabolism/pathology ; alpha-Synuclein/metabolism
[en] Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha-synuclein in precerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait, and impaired balance, which may be associated with cerebellar dysfunction. Therefore, we screened the cerebella of 12 patients with alpha-synucleinopathies for neuropathological changes. Cerebellar nuclei and neighboring white matter displayed numerous aggregates, whereas lobules were mildly affected. Cerebellar aggregation pathology may suggest a prionlike spread originating from affected precerebellar structures, and the high homogeneity between patients with dementia with Lewy bodies and Parkinson disease shows that both diseases likely belong to the same neuropathological spectrum. Ann Neurol 2017;81:898-903.
senkenberg foundation
http://hdl.handle.net/10993/32463
10.1002/ana.24937
(c) 2017 American Neurological Association.

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