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Article (Scientific journals)
Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.
Mandenius, Carl-Fredrik; Steel, Daniella; Noor, Fozia et al.
2011In Journal of Applied Toxicology, 31 (3), p. 191-205
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Keywords :
Animal Testing Alternatives; Animals; Cell Differentiation; Cell Line, Transformed; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions/classification; Heart Diseases/chemically induced/pathology/physiopathology; Humans; Myocytes, Cardiac/drug effects/metabolism/pathology; Oxygen Consumption; Pluripotent Stem Cells/cytology/drug effects; Xenobiotics/toxicity
Abstract :
[en] In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state-of-the-art bioanalytical methods and sensors is reviewed. The focus is on hESC-derived cells and their refinement into competent testing cells, but the access and utility of other relevant cell types are also discussed. Recent developments in sensor techniques and bioanalytical approaches for measuring critical cardiotoxicity parameters are highlighted, together with aspects of data evaluation and validation. Finally, recommendations for further research are given.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Mandenius, Carl-Fredrik
Steel, Daniella
Noor, Fozia ;  Saarland University > Biochemical Engineering
Meyer, Thomas
Heinzle, Elmar
Asp, Julia
Arain, Sarina
Kraushaar, Udo
Bremer, Susanne
Class, Reiner
Sartipy, Peter
External co-authors :
yes
Language :
English
Title :
Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.
Publication date :
2011
Journal title :
Journal of Applied Toxicology
ISSN :
1099-1263
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
Volume :
31
Issue :
3
Pages :
191-205
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 John Wiley & Sons, Ltd.
Available on ORBilu :
since 13 September 2017

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