Article (Scientific journals)
Modeling heterogeneity in the pluripotent state: A promising strategy for improving the efficiency and fidelity of stem cell differentiation
Espinosa Angarica, Vladimir; del Sol Mesa, Antonio
2016In BioEssays, 38 (8)
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Keywords :
pluripotent state; gene expression heterogeneity; gene regulatory networks; signalling pathway; epigenetics; stem cells
Abstract :
[en] Pluripotency can be considered a functional characteristic of pluripotent stem cells (PSCs) populations and their niches, rather than a property of individual cells. In this view, individual cells within the population independently adopt a variety of different expression states, maintained by different signaling, transcriptional, and epigenetics regulatory networks. In this review, we propose that generation of integrative network models from single cell data will be essential for getting a better understanding of the regulation of self-renewal and differentiation. In particular, we suggest that the identification of network stability determinants in these integrative models will provide important insights into the mechanisms mediating the transduction of signals from the niche, and how these signals can trigger differentiation. In this regard, the differential use of these stability determinants in subpopulation-specific regulatory networks would mediate differentiation into different cell fates. We suggest that this approach could offer a promising avenue for the development of novel strategies for increasing the efficiency and fidelity of differentiation, which could have a strong impact on regenerative medicine
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Espinosa Angarica, Vladimir ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
del Sol Mesa, Antonio ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
no
Language :
English
Title :
Modeling heterogeneity in the pluripotent state: A promising strategy for improving the efficiency and fidelity of stem cell differentiation
Publication date :
August 2016
Journal title :
BioEssays
ISSN :
1521-1878
Publisher :
Wiley Periodicals, New York, United States - New York
Volume :
38
Issue :
8
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
FnR Project :
FNR5810227 - Platform To Design New Strategies For Cellular Reprogramming In Regenerative Medicine, 2013 (01/02/2014-31/01/2017) - Antonio Del Sol Mesa
Name of the research project :
Platform to design new strategies for cellular reprogramming in regenerative medicine
Funders :
FNR - Fonds National de la Recherche [LU]
Available on ORBilu :
since 21 June 2016

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