Article (Scientific journals)
Dissipation in noisy chemical networks: The role of deficiency
Esposito, Massimiliano; Polettini, Matteo; Wachtel, Artur
2015In Journal of Chemical Physics, 145 (18), p. 184103
Peer Reviewed verified by ORBi
 

Files


Full Text
Dissipation in noisy chemical networks: The role of deficiency .pdf
Author postprint (963.97 kB)
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
biochemichal networks; single-cell; thermodynamics
Abstract :
[en] We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of complex behavior such as multistability and oscillations, is shown to also characterize the entropic balance. In particular, when deficiency is zero the average stochastic dissipation rate equals that of the corresponding deterministic model, where correlations are disregarded. In fact, dissipation can be reduced by the effect of noise, as occurs in a toy model of metabolism that we employ to illustrate our findings. This phenomenon highlights that there is a close interplay between deficiency and the activation of new dissipative pathways at low molecule numbers
Disciplines :
Physics
Author, co-author :
Esposito, Massimiliano  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
Polettini, Matteo ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
Wachtel, Artur ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
External co-authors :
no
Language :
English
Title :
Dissipation in noisy chemical networks: The role of deficiency
Publication date :
2015
Journal title :
Journal of Chemical Physics
ISSN :
1089-7690
Publisher :
American Institute of Physics, New York, United States - New York
Volume :
145
Issue :
18
Pages :
184103
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 22 April 2016

Statistics


Number of views
197 (22 by Unilu)
Number of downloads
125 (11 by Unilu)

Scopus citations®
 
25
Scopus citations®
without self-citations
19
OpenCitations
 
26
WoS citations
 
25

Bibliography


Similar publications



Contact ORBilu