Article (Scientific journals)
Biomarkers of postoperative delirium and cognitive dysfunction
Androsova, Ganna; Krause, Roland; Winterer, Georg et al.
2015In Frontiers in Aging Neuroscience, 7 (112)
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Abstract :
[en] Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers.
Disciplines :
Surgery
Life sciences: Multidisciplinary, general & others
Neurology
Author, co-author :
Androsova, Ganna ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Krause, Roland  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Winterer, Georg
Schneider, Reinhard ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Biomarkers of postoperative delirium and cognitive dysfunction
Publication date :
2015
Journal title :
Frontiers in Aging Neuroscience
ISSN :
1663-4365
Publisher :
Frontiers Media S.A., Switzerland
Volume :
7
Issue :
112
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
BioCog
Funders :
CE - Commission Européenne [BE]
Available on ORBilu :
since 07 November 2015

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