Article (Scientific journals)
Pacing-induced cardiomyopathy: pathophysiological insights through matrix metalloproteinases.
Ahmed, Fozia Z.; Khattar, Rajdeep S.; Zaidi, Amir M. et al.
2013In Heart Failure Reviews
Peer Reviewed verified by ORBi
 

Files


Full Text
Pacing-induced cardiomyopathy - pathophysiological insights through matrix metalloproteinases..pdf
Publisher postprint (454.08 kB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Pacemakers; Right ventricular pacing; Left ventricular dyssynchrony; Pacing-induced cardiomyopathy; Matrix metalloproteinases; Heart failure
Abstract :
[en] Pacing-induced ventricular dysfunction and pacing-induced cardiomyopathy (PiCMP) are recognized complications of chronic right ventricular pacing. Alterations in myocardial perfusion and sympathetic innervation contribute to the development of pacing-induced heart disease. However, it is unlikely that these are the only processes involved. Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the collagenous extracellular matrix and play a central role in left ventricular remodelling during the development of heart failure. While the pathophysiological mechanisms and altered MMP expression that occur in chronic pressure overload, ischaemic and non-ischaemic dilated cardiomyopathy have been defined, those that occur in the clinical setting of pacing-induced ventricular dysfunction and PiCMP have not been reported. Here we review the clinical epidemiology of pacing-induced ventricular dysfunction and discuss how data derived from animal models provide insight into how changes in MMP expression and function contribute to the development of PiCMP. The review concludes by exploring pacing strategies that may be used to prevent pacing-induced ventricular dysfunction.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Ahmed, Fozia Z.
Khattar, Rajdeep S.
Zaidi, Amir M.
Neyses, Ludwig ;  University of Luxembourg > Research Office
Oceandy, Delvac
Mamas, Mamas
Language :
English
Title :
Pacing-induced cardiomyopathy: pathophysiological insights through matrix metalloproteinases.
Publication date :
2013
Journal title :
Heart Failure Reviews
ISSN :
1573-7322
Publisher :
Kluwer Academic Publishers, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 16 October 2014

Statistics


Number of views
101 (0 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
11
Scopus citations®
without self-citations
11
OpenCitations
 
7
WoS citations
 
9

Bibliography


Similar publications



Contact ORBilu