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Article (Scientific journals)
14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.
Ubl, Andreas; Berg, Daniela; Holzmann, Carsten et al.
2002In Molecular Brain Research, 108 (1-2), p. 33-9
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Keywords :
14-3-3 Proteins; Aged; Alleles; Base Sequence; Chromosomes, Human, Pair 22; DNA Mutational Analysis; Female; Genotype; Humans; Immunohistochemistry; Lewy Bodies/chemistry/metabolism; Male; Middle Aged; Parkinson Disease/metabolism; Tyrosine 3-Monooxygenase/genetics/metabolism
Abstract :
[en] Mutations in alpha-synuclein have been identified in some rare families with autosomal dominant Parkinson's disease (PD). The synuclein gene family shares physical and functional homology with 14-3-3 proteins and binds to 14-3-3 proteins and to its ligands. We therefore investigated whether 14-3-3 proteins are also involved in the pathogenesis of PD. Here we demonstrate that 14-3-3 proteins are colocalized with Lewy bodies in PD. We investigated the 14-3-3 eta (YWHAH) gene by mutation analysis and association studies as it maps to human chromosome 22q12.1-q13.1, a region which has been recently implicated in PD and carried out immunohistochemical studies of Lewy bodies with two different 14-3-3 eta antibodies. In 358 sporadic and familial PD patients, disease causing mutations were not identified. Furthermore, association studies with intragenic polymorphisms do not provide evidence for an involvement of 14-3-3 eta in the pathogenesis of PD. In accordance with these findings, there was no staining of substantia nigra Lewy bodies with antibodies specific for the 14-3-3 eta subunit.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Disciplines :
Genetics & genetic processes
Author, co-author :
Ubl, Andreas
Berg, Daniela
Holzmann, Carsten
Krüger, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Berger, Klaus
Arzberger, Thomas
Bornemann, Antje
Riess, Olaf
Language :
English
Title :
14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.
Publication date :
2002
Journal title :
Molecular Brain Research
ISSN :
0169-328X
Publisher :
Elsevier, Netherlands
Volume :
108
Issue :
1-2
Pages :
33-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 27 June 2014

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