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Article (Scientific journals)
Pax: a murine multigene family of paired box-containing genes.
Walther, C.; Guenet, J. L.; Simon, D. et al.
1991In Genomics, 11 (2), p. 424-34
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Keywords :
Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Cloning, Molecular; Crosses, Genetic; DNA Probes; Drosophila/genetics; Genes, Regulator/genetics; Haplotypes; Mice/genetics; Molecular Sequence Data; Multigene Family/genetics; Polymorphism, Restriction Fragment Length; Reading Frames; Sequence Alignment
Abstract :
[en] A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine paired box-containing genes (Pax genes) have been described and one, Pax-1, has been associated with the developmental mutant phenotype undulated. Here we describe the paired boxes of three novel Pax genes, Pax-4, Pax-5, and Pax-6. Comparison of the eight murine paired domains of the mouse, the five Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises Pox meso, Pax-1, and HuP48; class II paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III Pax-2, Pax-5, and Pax-8; class IV Pax-4; class V Pox neuro; and class VI Pax-6. Pax-1 and the human gene HuP48 have identical paired domains, as do Pax-3 and HuP2 as well as Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of Pax-3 and Pax-7 has been determined and reveals that they are not clustered.
Disciplines :
Genetics & genetic processes
Author, co-author :
Walther, C.
Guenet, J. L.
Simon, D.
Deutsch, U.
Jostes, B.
Goulding, M. D.
Plachov, D.
Balling, Rudi 
Gruss, P.
Language :
English
Title :
Pax: a murine multigene family of paired box-containing genes.
Publication date :
1991
Journal title :
Genomics
ISSN :
1089-8646
Publisher :
Elsevier, Atlanta, Georgia
Volume :
11
Issue :
2
Pages :
424-34
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 10 May 2013

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