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Article (Scientific journals)
Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.
Balling, Rudi; Mutter, G.; Gruss, P. et al.
1989In Cell, 58 (2), p. 337-47
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Keywords :
Abnormalities, Multiple/etiology/genetics/pathology; Actins/genetics; Animals; DNA-Binding Proteins/genetics; Facial Bones/abnormalities; Female; Gene Expression Regulation; Genes, Homeobox; Homeodomain Proteins; Male; Mice; Mice, Transgenic; Neoplasm Proteins; Neural Crest/cytology; Phenotype; Promoter Regions, Genetic; Skull/abnormalities; Transcription, Genetic
Abstract :
[en] Hox-1.1 is a murine homeobox-containing gene expressed in a time- and cell-specific manner during embryogenesis. We have generated transgenic mice that ectopically express Hox-1.1 from the chicken beta-actin promoter. In these mice Hox-1.1 expression was changed to an almost ubiquitous pattern. Ectopic expression of Hox-1.1 leads to death of the transgenic animals shortly after birth and is associated with multiple craniofacial anomalies, such as cleft palate, open eyes at birth, and nonfused pinnae. This phenotype is similar to the effects seen after systemic administration of retinoic acid during gestation. This suggests that retinoic acid embryopathy and the specific developmental defects caused by ectopic expression of a potential developmental control gene share a common pathogenic mechanism.
Disciplines :
Genetics & genetic processes
Author, co-author :
Balling, Rudi 
Mutter, G.
Gruss, P.
Kessel, M.
Language :
English
Title :
Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.
Publication date :
1989
Journal title :
Cell
ISSN :
1097-4172
Publisher :
Cell Press, United States - Massachusetts
Volume :
58
Issue :
2
Pages :
337-47
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 10 May 2013

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