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Keywords :
Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Chromosome Mapping; DNA; DNA Probes; Drosophila/genetics; Electrophoresis, Agar Gel; Embryonic and Fetal Development; Genes, Homeobox; Intestines/cytology/embryology; Mice; Molecular Sequence Data; Sequence Homology, Nucleic Acid; Species Specificity; Transcription, Genetic
Abstract :
[en] A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm.
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