Article (Scientific journals)
Emergence of the silicon human and network targeting drugs
Kolodkin, Alexey; Boogerda, Fred C.; Plantb, Nick et al.
2012In European Journal of Pharmaceutical Sciences, 46 (4), p. 190-197
Peer reviewed
 

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Keywords :
Systems biology; Emergence; Silicon human; Network targeting drugs; Nuclear receptors
Abstract :
[en] The development of disease may be characterized as a pathological shift of homeostasis; the main goal of contemporary drug treatment is, therefore, to return the pathological homeostasis back to the normal physiological range. From the view point of systems biology, homeostasis emerges from the interactions within the network of biomolecules (e.g. DNA, mRNA, proteins), and, hence, understanding how drugs impact upon the entire network should improve their efficacy at returning the network (body) to physiological homeostasis. Large, mechanism-based computer models, such as the anticipated human whole body models (silicon or virtual human), may help in the development of such network-targeting drugs. Using the philosophical concept of weak and strong emergence, we shall here take a more general look at the paradigm of network-targeting drugs, and propose our approaches to scale the strength of strong emergence. We apply these approaches to several biological examples and demonstrate their utility to reveal principles of bio-modeling. We discuss this in the perspective of building the silicon human.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Disciplines :
Human health sciences: Multidisciplinary, general & others
Identifiers :
UNILU:UL-ARTICLE-2011-433
Author, co-author :
Kolodkin, Alexey ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Boogerda, Fred C.
Plantb, Nick
Bruggemana, Frank J.
Goncharuke, Valeri
Lunshofa, Jeantine
Moreno-Sanchezi, Rafael
Yilmaza, Nilgun
Bakkerk, Barbara M.
Snoepa, Jacky L.
Balling, Rudi ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Westerhoff, Hans V.
External co-authors :
yes
Language :
English
Title :
Emergence of the silicon human and network targeting drugs
Publication date :
2012
Journal title :
European Journal of Pharmaceutical Sciences
ISSN :
0928-0987
Publisher :
Elsevier
Volume :
46
Issue :
4
Pages :
190-197
Peer reviewed :
Peer reviewed
Commentary :
in press
Available on ORBilu :
since 10 May 2013

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