![]() ![]() ; Bueb, Jean-Luc ![]() in Trends in Pharmacological Sciences (1990), 11(9), 358-62 The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these ... [more ▼] The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these effects are inhibited by pertussis toxin and involve a transient increase in IP3, no selective membrane receptors have been identified. However, it has recently been shown that these compounds activate G proteins in vitro. Here Yves Landry and colleagues discuss the proposal that direct activation of G protein is the physiological mechanism of action of substance P on rat peritoneal mast cells, this mechanism being mimicked by mastoparan and 48/80, and possibly by other cationic amphiphilic peptides such as kinins. These compounds might be of help in defining the interaction between membrane receptors and G proteins. [less ▲] Detailed reference viewed: 48 (0 UL)![]() Gawron, Piotr ![]() in Bulletin of the Polish Academy of Sciences. Technical Sciences (2014) Detailed reference viewed: 36 (0 UL)![]() ![]() ; Bueb, Jean-Luc ![]() in Agents and Actions (1991), 33(1-2), 81-3 The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin ... [more ▼] The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin (100 ng/ml) inhibited histamine release induced by compound 48/80, substance P, mastoparan, peptide 401, bradykinin and spermine showing that a G-protein sensitive to pertussis toxin was involved in the non-immunological histamine release. All these compounds directly activate purified G-proteins. The sensitivity to pertussis toxin of this direct stimulatory effect was demonstrated for compound 48/80, mastoparan and substance P. Altogether these results suggest that a direct activation of G-protein might be the molecular mechanism of action of histamine secretagogues acting through a pertussis toxin sensitive G-protein and in this way mimic agonist-ligand receptor interaction. [less ▲] Detailed reference viewed: 45 (1 UL)![]() ; ; et al in ASDAM 2012, The Ninth International Conference on Advanced Semiconductor Devices and Microsystems (2012) Detailed reference viewed: 55 (0 UL)![]() ; Marso, Michel ![]() in Applied Physics Letters (2006), 89 The authors report on the fabrication and characterization of photodetectors based on nitrogen-ion-implanted GaAs and the annealing dynamics in these devices. An energy of 400 keV was used to implant N ... [more ▼] The authors report on the fabrication and characterization of photodetectors based on nitrogen-ion-implanted GaAs and the annealing dynamics in these devices. An energy of 400 keV was used to implant N ions in a GaAs substrate at an ion concentration of 1 1016 cm−2. Dark current measurements as well as measurements under illumination show that the material properties rapidly change during the annealing process. Photodetectors based on nitrogen-implanted GaAs materials with annealing temperatures up to 400 °C exhibit a subpicosecond carrier lifetime up to 0.6 ps. These properties make nitrogen-ion-implanted GaAs an ideal material for ultrafast photodetectors, as alternative to low-temperature-grown GaAs. [less ▲] Detailed reference viewed: 30 (1 UL)![]() ![]() Hanesch, Ulrike ![]() in Pain (2003), 104 Detailed reference viewed: 19 (0 UL)![]() Cuniberti, Gilles ![]() in Petites Affiches, la Loi (1999) Detailed reference viewed: 18 (0 UL)![]() Machado Carneiro, Joël ![]() Presentation (2016) Detailed reference viewed: 38 (0 UL)![]() Machado Carneiro, Joël ![]() Presentation (2016, May) Detailed reference viewed: 85 (3 UL)![]() Machado Carneiro, Joël ![]() Presentation (2016, April) Detailed reference viewed: 29 (2 UL)![]() Machado Carneiro, Joël ![]() Scientific Conference (2015) Detailed reference viewed: 31 (3 UL)![]() Marso, Michel ![]() in Proceedings of the 18th European Solid State Device Research Conference (ESSDERC 88), Montpellier, France, 1988, J. de Physique, Colloque C4, suppl. 9 (1988) Detailed reference viewed: 19 (0 UL)![]() Marso, Michel ![]() in Electronics Letters (1989), 25(1989), 1462-1463 Detailed reference viewed: 20 (0 UL)![]() Marso, Michel ![]() in Electronics Letters (1991), 27(1991), 335-337 Detailed reference viewed: 19 (0 UL)![]() Ferring, Dieter ![]() ![]() Scientific Conference (2017) Caring for a close person involves and impacts several aspects and domains of personal life. A scenario that is often sketched here indicates that caring is physically exhausting, demanding time, leaving ... [more ▼] Caring for a close person involves and impacts several aspects and domains of personal life. A scenario that is often sketched here indicates that caring is physically exhausting, demanding time, leaving no time for leisure, and excluding the carer from further social activities. In this view, caring is strain as it is clearly described by the concept of caregiver burden, and a risk for the psychological and/or physical health of family carers. But caring may also have another side of positive gratification and of fulfilment. To care for another person may represent a meaningful work for both the cared for and the caring person that may also go along with recognition and positive feedback from others. This is the starting point of the present study that addressed a sample of 151 informal carers (n = 111 female) with a mean age of 58 years (SD=14 years) with self-report questionnaire. The measure offered in a first part positive (n=35) and negative aspects (n=23) of caring for a close person and subjects had to rate how much they agree that these aspects are present in their own care giving relationship. Moreover, life satisfaction as well as positive and negative affect were assessed in a second part. Multivariate analyses by factor as well as cluster analyses showed different profiles of gains and losses that were systematically linked to indicators of subjective well-being. Findings will be discussed with respect to their implications for psychosocial intervention in the field of informal care. [less ▲] Detailed reference viewed: 37 (4 UL)![]() ; Van Der Meulen, Marian ![]() in Swiss Archives of Neurology and Psychiatry (2010), 161(6), 195-199 Detailed reference viewed: 49 (1 UL)![]() Molina Blanco, Santiago ![]() E-print/Working paper (2013) Detailed reference viewed: 18 (2 UL)![]() Arias De Reyna Dominguez, Sara ![]() in Bertin, Marie José; Bucur, Alina; Feigon, Brooke (Eds.) et al Women in Numbers Europe Research Directions in Number Theory (2015) In this paper we generalize results of P. Le Duff to genus n hyperelliptic curves. More precisely, let C/Q be a hyperelliptic genus n curve and let J(C) be the associated Jacobian variety. Assume that ... [more ▼] In this paper we generalize results of P. Le Duff to genus n hyperelliptic curves. More precisely, let C/Q be a hyperelliptic genus n curve and let J(C) be the associated Jacobian variety. Assume that there exists a prime p such that J(C) has semistable reduction with toric dimension 1 at p. We provide an algorithm to compute a list of primes l (if they exist) such that the Galois representation attached to the l-torsion of J(C) is surjective onto the group GSp(2n, l). In particular we realize GSp(6, l) as a Galois group over Q for all primes l in [11, 500000]. [less ▲] Detailed reference viewed: 48 (9 UL)![]() Arias De Reyna Dominguez, Sara ![]() Scientific Conference (2013, October 14) Detailed reference viewed: 19 (2 UL) |
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