G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides

in Trends in Pharmacological Sciences (1990), 11(9), 358-62

The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these ... [more ▼]

The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these effects are inhibited by pertussis toxin and involve a transient increase in IP3, no selective membrane receptors have been identified. However, it has recently been shown that these compounds activate G proteins in vitro. Here Yves Landry and colleagues discuss the proposal that direct activation of G protein is the physiological mechanism of action of substance P on rat peritoneal mast cells, this mechanism being mimicked by mastoparan and 48/80, and possibly by other cationic amphiphilic peptides such as kinins. These compounds might be of help in defining the interaction between membrane receptors and G proteins. [less ▲]

G-DNA – a highly efficient multi-GPU/MPI tool for aligning nucleotide reads

in Bulletin of the Polish Academy of Sciences. Technical Sciences (2014)

GaAs nanowhiskers for femtosecond photodetectors and THz emitters

in ASDAM 2012, The Ninth International Conference on Advanced Semiconductor Devices and Microsystems (2012)

Gabapentin reduces the mechanosensitivity of fine afferent nerve fibres in normal and inflamed rat knee joints.

in Pain (2003), 104

Gagner sa vie au volant au risque de la perdre: Les pilotes automobiles européens (années 1920-1930)

in Mouvement Social (2016), 254

This article deals with the emergence of a group of professional automobile pilots in Europe during the Interwar period. During the time, automobile racing was institutionalised and commercialised to a ... [more ▼]

This article deals with the emergence of a group of professional automobile pilots in Europe during the Interwar period. During the time, automobile racing was institutionalised and commercialised to a previously unknown extent, under the supervision of European automobile clubs, industrial groups and journalists. In this context, by following the trajectories of pilots, we study the conditions for exercising this practice – part sport, part social activity. These trajectories are mainly marked by a wide diversity due to the sport’s origins, at the crossroads of changes in bourgeois leisure activities and the unprecedented development of the automobile industry. On the roads and race tracks of Europe, racing team pilots came up against wealthy independent racers, forming a stratified population and a wide range of participants with diverse origins, mobility, motivations and compensation. In the representations of the period, the pilots became the icons of the triumph of the automobile, but they nevertheless took second stage to the industrial groups that employed and equipped them. In this European space that was driven across and appropriated, behind the sports competition that acted as a support, this situation gave rise to large-scale industrial competitions and strategies that benefited the sportsmen but also held them captive. [less ▲]

The Gain from the Drain: Welfare effects of Selective Migration

Presentation (2016, May)

The Gain from the Drain: Welfare effects of Selective Migration

Scientific Conference (2015)

GaInAs Camel Transistors Grown by MOCVD

in Electronics Letters (1989), 25(1989), 1462-1463

Gains and losses of caring for an older relative and the indication for geropsychological intervention

Scientific Conference (2017)

Caring for a close person involves and impacts several aspects and domains of personal life. A scenario that is often sketched here indicates that caring is physically exhausting, demanding time, leaving ... [more ▼]

Caring for a close person involves and impacts several aspects and domains of personal life. A scenario that is often sketched here indicates that caring is physically exhausting, demanding time, leaving no time for leisure, and excluding the carer from further social activities. In this view, caring is strain as it is clearly described by the concept of caregiver burden, and a risk for the psychological and/or physical health of family carers. But caring may also have another side of positive gratification and of fulfilment. To care for another person may represent a meaningful work for both the cared for and the caring person that may also go along with recognition and positive feedback from others. This is the starting point of the present study that addressed a sample of 151 informal carers (n = 111 female) with a mean age of 58 years (SD=14 years) with self-report questionnaire. The measure offered in a first part positive (n=35) and negative aspects (n=23) of caring for a close person and subjects had to rate how much they agree that these aspects are present in their own care giving relationship. Moreover, life satisfaction as well as positive and negative affect were assessed in a second part. Multivariate analyses by factor as well as cluster analyses showed different profiles of gains and losses that were systematically linked to indicators of subjective well-being. Findings will be discussed with respect to their implications for psychosocial intervention in the field of informal care. [less ▲]

Galois action on the L-isogeny classes of abelian surfaces with quaternionic multiplication

E-print/Working paper (2013)