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See detailTrajectory Tracking for Robotic Freeform Grinding
Klecker, Sophie UL; Plapper, Peter UL

in Cahier Scientifique - Revue Technique Luxembourgeoise (2016), 1(2016), 6-7

Unergonomic working conditions, a decline in available labour force and uncompetitively high salaries make automation an attractive solution for a variety of manufacturing processes. To achieve successful ... [more ▼]

Unergonomic working conditions, a decline in available labour force and uncompetitively high salaries make automation an attractive solution for a variety of manufacturing processes. To achieve successful automation of even complex, contact-based manufacturing processes, inspiration is more and more found in nature. In this work, a biomimetic approach is chosen to address the grinding process of freeform geometries by industrial robots. [less ▲]

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See detailDie Tranchot-Müffling-Karte (1801-1828)
Helfer, Malte UL; Pauly, Michel UL; Caruso, Geoffrey UL et al

E-print/Working paper (2009)

Die Tranchot-Müffling-Karte deckt als historische topographische Karte aus dem frühen 19. Jahrhundert den deutschen Teil der Großregion SaarLorLux ab. Gemeinsam mit der Cassini-Karte für den französischen ... [more ▼]

Die Tranchot-Müffling-Karte deckt als historische topographische Karte aus dem frühen 19. Jahrhundert den deutschen Teil der Großregion SaarLorLux ab. Gemeinsam mit der Cassini-Karte für den französischen Bereich sowie der Ferraris-Karte für den wallonischen Teil sowie das Großherzogtum Luxemburg kann so die Situation fast der gesamten Großregion SaarLorLux vor den umwälzenden Veränderungen durch die industrielle Revolution dargestellt werden. [less ▲]

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See detailTrans und sozialer Wandel in der Bundesrepublik Deutschland
De Silva, Adrian UL

in Hoenes, Josch; Koch, Michael_a (Eds.) Transfer und Interaktion: Wissenschaft und Aktivismus an den Grenzen heteronormativer Zweigeschlechtlichkeit (2017)

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See detailTrans* in Sexualwissenschaft und Recht vor Inkrafttreten des Transsexuellengesetzes
De Silva, Adrian UL

in Schmelzer, Christian (Ed.) Gender Turn: Gesellschaft jenseits der Geschlechternorm (2013)

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See detailTrans-Interfacial Polymerization and Matter Transport Processes in Epoxy-Alumina Nanocomposites Visualized By Scanning Brillouin Microscopy
Sanctuary, Roland UL; Philipp, Martine UL; Kieffer, J. et al

in Journal of Physical Chemistry B (2010), 114(25), 8396-8404

The structural developments in the vicinity of the interface between the reactants of an epoxy are investigated using time- and space-resolved scanning Brillouin microscopy. The hypersonic profile across ... [more ▼]

The structural developments in the vicinity of the interface between the reactants of an epoxy are investigated using time- and space-resolved scanning Brillouin microscopy. The hypersonic profile across the phase boundary evolves with strong spatial asymmetry and exhibits erratic behavior within the resin-rich region, which is attributed to a complex interplay between matter transport, dissolution, polymerization, and molecular unravelling process. The presence of alumina nanoparticles in the resin changes the character of these matter transport and reaction processes significantly. On the one hand, the nanoparticles act as transport barriers, hindering the mixing of the reactive components; on the other hand they seem to have a catalytic influence on the epoxy polymerization under certain circumstances. Their transport against gravity is tentatively attributed to gradients in surface tension. [less ▲]

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See detailTransactie, ervaring en kennen: Het cultureel-naturalisme van John Dewey
Biesta, Gert UL; Miedema, S.

in Pennings, A.; A. van der Leij; Meeus, W. (Eds.) et al Bijdragen aan Pedagogisch Onderzoek 1990. (1991)

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See detailTransatlantic Perspectives on Administrative Law
Hofmann, Herwig UL

Book published by Bruylant (2011)

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See detailTransatlantic Perspectives on Administrative Law - an Introduction
Hofmann, Herwig UL

in HOFMANN, Herwig C. H.; WEAVER, Russell L. (Eds.) Transatlantic Perspectives on Administrative Law (2011)

This book focuses on two important trends in the future of Administrative Law. The first is the relevance of administrative law for developing legitimacy and accountability of multi-level regulatory ... [more ▼]

This book focuses on two important trends in the future of Administrative Law. The first is the relevance of administrative law for developing legitimacy and accountability of multi-level regulatory systems. In a time of global trade in goods and services, as well as increasing interconnectedness of public institutions, administrative law is in a period of growth and transformation. This book examines these transformations in the context of global administrative law, as evidenced by increasing interest in the nature and conditions of EU administrative law, and the movement towards increasingly intense regulatory cooperation in bilateral settings (for example EU-US) as well as multilateral fora (for example in international organizations such as the WTO). [less ▲]

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See detailTransceiver design for distributed STBC based AF cooperative networks in the presence of timing and frequency offsets
Nasir, A.A.; Mehrpouyan, H.; Durrani, S. et al

in IEEE Transactions on Signal Processing (2013), 12(61), 3143-3158

In multi-relay cooperative systems, the signal at the destination is affected by impairments such as multiple channel gains, multiple timing offsets (MTOs), and multiple carrier frequency offsets (MCFOs ... [more ▼]

In multi-relay cooperative systems, the signal at the destination is affected by impairments such as multiple channel gains, multiple timing offsets (MTOs), and multiple carrier frequency offsets (MCFOs). In this paper we account for all these impairments and propose a new transceiver structure at the relays and a novel receiver design at the destination in distributed space-time block code (DSTBC) based amplify-and-forward (AF) cooperative networks. The Cramér-Rao lower bounds and a least squares (LS) estimator for the multi-parameter estimation problem are derived. In order to significantly reduce the receiver complexity at the destination, a differential evolution (DE) based estimation algorithm is applied and the initialization and constraints for the convergence of the proposed DE algorithm are investigated. In order to detect the signal from multiple relays in the presence of unknown channels, MTOs, and MCFOs, novel optimal and sub-optimal minimum mean-square error receiver designs at the destination node are proposed. Simulation results show that the proposed estimation and compensation methods achieve full diversity gain in the presence of channel and synchronization impairments in multi-relay AF cooperative networks. [less ▲]

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See detailTransceiver design of optimum wirelessly powered full-duplex MIMO IoT devices
Xue, Jiang; Biswas, Sudip; Cirik, Ali Cagatay et al

in IEEE Transactions on Communications (2018)

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See detailTranscendence, revelation and the constructivist classroom; or: in praise of teaching.
Biesta, Gert UL

in Philosophy of Education Yearbook (2011)

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See detailTranscranial ultrasound in different monogenetic subtypes of Parkinson's disease.
Schweitzer, Katherine J.; Brussel, Theresa; Leitner, Petra et al

in Journal of neurology (2007), 254(5), 613-6

Hyperechogenicity of the substantia nigra (SN) has been found to be a typical sign in idiopathic Parkinson's disease (PD), prevalent in more than 90% of affected individuals. To see whether SN ... [more ▼]

Hyperechogenicity of the substantia nigra (SN) has been found to be a typical sign in idiopathic Parkinson's disease (PD), prevalent in more than 90% of affected individuals. To see whether SN hyperechogenicity is also characteristic for monogenetically caused PD, we investigated PD patients with alpha-synuclein, LRRK2, parkin, PINK1 and DJ-1 mutations by transcranial sonography (TCS). In all these patients the area of SN echogenicity was significantly larger than in healthy controls, but smaller, than in idiopathic PD. As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD. [less ▲]

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See detailTranscriptional activity of the octamer motif in embryonic stem cells and preimplantation embryos
Schöler, H. R.; Balling, Rudi UL; Hatzopoulos, A. K. et al

in Hormones and Cell Regulation (1989), 198(14), 91-95

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See detailTranscriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+).
Krug, AK.; Gutbier, S.; Zhao, L. et al

in Cell Death & Disease (2013)

Assessment of the network of toxicity pathways by Omics technologies and bioinformatic data processing paves the road toward a new toxicology for the twenty-first century. Especially, the upstream network ... [more ▼]

Assessment of the network of toxicity pathways by Omics technologies and bioinformatic data processing paves the road toward a new toxicology for the twenty-first century. Especially, the upstream network of responses, taking place in toxicanttreated cells before a point of no return is reached, is still little explored. We studied the effects of the model neurotoxicant 1-methyl-4-phenylpyridinium (MPPþ) by a combined metabolomics (mass spectrometry) and transcriptomics (microarrays and deep sequencing) approach to provide unbiased data on earliest cellular adaptations to stress. Neural precursor cells (LUHMES) were differentiated to homogeneous cultures of fully postmitotic human dopaminergic neurons, and then exposed to the mitochondrial respiratory chain inhibitor MPPþ (5 lM). At 18–24 h after treatment, intracellular ATP and mitochondrial integrity were still close to control levels, but pronounced transcriptome and metabolome changes were seen. Data on altered glucose flux, depletion of phosphocreatine and oxidative stress (e.g., methionine sulfoxide formation) confirmed the validity of the approach. New findings were related to nuclear paraspeckle depletion, as well as an early activation of branches of the transsulfuration pathway to increase glutathione. Bioinformatic analysis of our data identified the transcription factor ATF-4 as an upstream regulator of early responses. Findings on this signaling pathway and on adaptive increases of glutathione production were confirmed biochemically. Metabolic and transcriptional profiling contributed complementary information on multiple primary and secondary changes that contribute to the cellular response to MPPþ. Thus, combined ‘Omics’ analysis is a new unbiased approach to unravel earliest metabolic changes, whose balance decides on the final cell fate. [less ▲]

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See detailTranscriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+).
Hiller, Karsten UL

in Cell Death & Differentiation (2013)

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See detailTranscriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more
Turner, Jonathan D.; Alt, Simone UL; Cao, Lei et al

in Biochemical Pharmacology (2010), 80(12), 1860-68

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See detailTranscriptional mechanisms underlying sensitization of peripheral sensory neurons by Granulocyte-/Granulocyte-macrophage colony stimulating factors.
Bali, Kiran Kumar; Venkataramani, Varun; Satagopam, Venkata UL et al

in Molecular pain (2013), 9(1), 48

BACKGROUND: Cancer-associated pain is a major cause of poor quality of life in cancer patients and is frequently resistant to conventional therapy. Recent studies indicate that some hematopoietic growth ... [more ▼]

BACKGROUND: Cancer-associated pain is a major cause of poor quality of life in cancer patients and is frequently resistant to conventional therapy. Recent studies indicate that some hematopoietic growth factors, namely granulocyte macrophage colony stimulating factor (GMCSF) and granulocyte colony stimulating factor (GCSF), are abundantly released in the tumor microenvironment and play a key role in regulating tumor-nerve interactions and tumor-associated pain by activating receptors on dorsal root ganglion (DRG) neurons. Moreover, these hematopoietic factors have been highly implicated in postsurgical pain, inflammatory pain and osteoarthritic pain. However, the molecular mechanisms via which G-/GMCSF bring about nociceptive sensitization and elicit pain are not known. RESULTS: In order to elucidate G-/GMCSF mediated transcriptional changes in the sensory neurons, we performed a comprehensive, genome-wide analysis of changes in the transcriptome of DRG neurons brought about by exposure to GMCSF or GCSF. We present complete information on regulated genes and validated profiling analyses and report novel regulatory networks and interaction maps revealed by detailed bioinformatics analyses. Amongst these, we validate calpain 2, matrix metalloproteinase 9 (MMP9) and a RhoGTPase Rac1 as well as Tumor necrosis factor alpha (TNFalpha) as transcriptional targets of G-/GMCSF and demonstrate the importance of MMP9 and Rac1 in GMCSF-induced nociceptor sensitization. CONCLUSION: With integrative approach of bioinformatics, in vivo pharmacology and behavioral analyses, our results not only indicate that transcriptional control by G-/GMCSF signaling regulates a variety of established pain modulators, but also uncover a large number of novel targets, paving the way for translational analyses in the context of pain disorders. [less ▲]

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See detailTranscriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR
Margue, Christiane UL; Bernasconi, Michele; Barr, Frederik et al

in Oncogene (2000), 19(25), 2921

The aberrant expression of the transcription factors PAX3 and PAX3/FKHR associated with rhabdomyosarcoma (RMS), solid tumors displaying muscle cell features, suggests that these proteins play an important ... [more ▼]

The aberrant expression of the transcription factors PAX3 and PAX3/FKHR associated with rhabdomyosarcoma (RMS), solid tumors displaying muscle cell features, suggests that these proteins play an important role in the pathogenesis of RMS. We could previously demonstrate that one of the oncogenic functions of PAX3 and PAX3/FKHR in RMS is protection from apoptosis. BCL-XL is a prominent anti-apoptotic protein present in normal skeletal muscle and RMS cells. In the present study, we establish that BCL-XL is transcriptionally modulated by PAX3 and PAX3/FKHR, since enhanced expression of both PAX proteins stimulates transcription of endogenous BCL-XL mRNA in a cell type specific manner. Further, we present evidence that both PAX3 and PAX3/FKHR can transcriptionally activate the Bcl-x gene promoter in cotransfection assays. Using electrophoretic mobility shift assays, an ATTA binding site for PAX3 and PAX3/FKHR could be localized in the upstream promoter region (position -42 to -39). Finally, ectopic overexpression of either PAX3, PAX3/FKHR or BCL-XL can rescue tumor cells from apoptosis induced by antisense treatment. These results suggest that at least part of the anti-apoptotic effect of PAX3 and PAX3/FKHR is mediated through direct transcriptional modulation of the prominent anti-apoptotic protein BCL-XL. [less ▲]

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